Structure-activity relationships (SAR) analysis is crucial in drug discovery. By altering the chemical structure of a lead compound and observing the resulting biological activity, researchers determine the key structural features responsible for efficacy. This knowledge guides further design of novel therapeutic agents with improved pharmacologica

The management of chronic pain often involves a multi-faceted approach, incorporating pharmacological interventions designed to modulate various physiological pathways involved in pain perception and transmission. Commonly employed drug classes include nonsteroidal anti-inflammatory drugs (NSAIDs), which exert their symptom-altering effects by inhi